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Recent Research Reports

Repetitive Transcranial Magnetic Stimulation of the Supplementary Motor Area in the treatment of Tourette Syndrome: Report of two cases.
Mantovani A, Leckman JF, Grantz H, King RA, Sporn AL, Lisanby SH.
Clinical Neurophysiology . 2007 Aug 18

Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome.
Behen M, Chugani HT, Juhasz C, Helder E, Ho A, Maqbool M, Rothermel RD, Perry J, Muzik O.
Movement Disorders. 2007 Aug 20

Technical aspects and considerations of deep brain stimulation surgery for movement disorders.
Sakas DE , Kouyialis AT, Boviatsis EJ, Panourias IG, Stathis P, Tagaris G.
Acta Neurochirurgica Supplement 2007;97(Pt 2):163-70.

Association study between gilles de la tourette syndrome and two genes in the robo-slit pathway located in the chromosome 11q24 linked/associated region.
Miranda DM, Wigg K, Feng Y, Sandor P, Barr CL.
American Journal of Medical Genetics, Part B, Neuropsychiatric genetics. 2007 Aug 1

Tourette syndrome and tic disorders: a decade of progress.
Swain JE, Scahill L, Lombroso PJ, King RA, Leckman JF.
Journal of the American Academy of Child & Adolescent Psychiatry. 2007 Aug

Role of the novel tryptophan hydroxylase-2 gene in Tourette syndrome.
Mossner R, Muller-Vahl KR, Doring N, Stuhrmann M.
Molecular Psychiatry. 2007 Jul

A double blind randomized placebo control trial of levetiracetam in tourette syndrome.
Smith-Hicks CL, Bridges DD, Paynter NP, Singer HS.
Movement Disorders. 2007 Jun 12

Frontal dopaminergic abnormality in Tourette syndrome: A postmortem analysis.
Journal of Neurological Science , March 2, 2007
Results support the hypothesis of a dopaminergic dysfunction in the frontal lobe and a likely role in the pathophysiology of TS.

Genome scan for tourette disorder in affected-sibling-pair and multigenerational families.
American Journal of Human Genetics, 2007 Feb
Strong evidence of linkage was observed for a region on chromosome 2p in the analyses that included individuals with TD or CT disorder as affected.

Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive-compulsive disorder.
Journal of Child Psychology and Psychiatry , 2007 Feb
The impact of antecedent psychosocial adversity is greater on future depressive symptoms than for tic and/or OC symptoms. Worsening OC symptoms are also a predictor of future depressive symptoms. Advancing chronological age is robustly associated with reductions in tic severity.

GPi deep brain stimulation for Tourette syndrome improves tics and psychiatric comorbidities.
Neurology, 2007 Jan 9

Antineuronal antibodies in a group of children with obsessive-compulsive disorder and Tourette syndrome.
Journal of Psychiatric Research , 2006 Nov 16
Though the study supports the hypothesis of an autoimmune process underlying OCD or TS in some patients, further research is needed.

Antineuronal antibodies in a group of children with obsessive-compulsive disorder and Tourette syndrome.
Journal of Psychiatric Research. Nov 16, 2006

The future of genomic profiling of neurological diseases using blood.
Archives of Neurology. Nov 2006

Examination of the SLITRK1 gene in Caucasian patients with Tourette syndrome.
Acta Neurologica Scandinavica. Dec 2006

Reduced white matter connectivity in the corpus callosum of children with Tourette syndrome.
Journal of Child Psychology and Psychiatry. Nov 2006

Botulinum Toxin in the Management of Laryngeal Tics.
Journal of Voice. Oct 20, 2006

Functional brain asymmetry, attentional modulation, and interhemispheric transfer in boys with Tourette syndrome.
Neuropsychologia. 2006 Oct 10, 2006

A case series of patients with Tourette's syndrome in the United Kingdom treated with aripiprazole.
Human Psychopharmacology. Oct 2006

Identification of pyruvate kinase as an antigen associated with Tourette syndrome.
Journal of Neuroimmunology. Sep 29, 2006

Decreased Numbers of Regulatory T Cells Suggest Impaired Immune Tolerance in Children with Tourette Syndrome: A Preliminary Study.
Biological Psychiatry. Sep 21, 2006

Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome.
Movement Disorders. Sep 21, 2006

Increased antistreptococcal antibody titers and anti-basal ganglia antibodies in patients with Tourette syndrome: controlled cross-sectional study.
Journal of Child Neurology. Sep 2006

Autoimmune neuropsychiatric disorders associated with streptococcal infection: Sydenham chorea, PANDAS, and PANDAS variants.
Journal of Child Neurology. Sep 2006

To read more about these studies, visit the PubMed website, and type in Tourette as the keyword.